Straightforward Ring Expansion of Pyroglutamates to Perhydro-1,3-diazepine-2,4-diones
نویسندگان
چکیده
منابع مشابه
Conformational analysis and synthetic approaches to polydentate perhydro-diazepine ligands for the complexation of gallium(III).
Synthetic approaches are reported to polydentate ligands based on 6-phenyl-6-amino-perhydro-1,4-diazepine. The synthetic route devised averts ring-opening reactions, allowing the exocyclic N-substituent to be introduced separately and involves a nitro-Mannich condensation, prior to chemoselective RANEY® nickel reduction. Comparison of the solid-state structures of four synthetic intermediates r...
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Electrophilic ring opening of spiro-cyclopropanecarboxylated sugars followed by reaction with DBU revealed interesting ring-contraction and ring-expansion reactions depending on the substrate and the kind of hydroxyl protective group present adjacent to the spiro center. A stereoselective method for accessing a new class of carbon chain extended keto-furanoses and C-glycosylated bicyclic compou...
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Various macrocycles were prepared in one step by a novel ring-expansion method using olefin metathesis.
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A mutant of Cephalosporium acremonium producing high amounts of penicillin N was isolated. This antibiotic was purified and characterized. It was possible to convert this penicillin N to deacetoxycephalosporin C enzymatically. The reaction could be carried out with enzyme systems prepared from C. acremonium mutants producing either no S-lactam antibiotics or excreting only penicillin N. It was ...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2005
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol052428e